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Does retatrutide increase heart rate?

Yes. In the obesity dose-finding trial heart rate rose with dose, peaked at 24 weeks and then declined.

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

Yes. In the obesity dose-finding trial heart rate rose with dose, peaked at 24 weeks and then declined.[1]

A meta-analysis of randomised trials in people without diabetes found retatrutide raised heart rate by a mean difference of 3.46 against placebo (95% CI 1.74 to 5.18).[2]

What else the papers report

A commentary on the early diabetes trial reported a rise of up to 6.7 beats per minute and said it may be detrimental.[3]

A review also noted mild to moderate cardiac arrhythmias and said long-term cardiovascular outcome trials will be critical.[4]

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More on Retatrutide

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Sources

  1. 1Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial.The New England journal of medicine · 2023PMID 37366315Accessed 2 Oct 2026
  2. 2Effect of glucagon-like peptide-1 receptor agonists on heart rate in non-diabetic individuals with overweight or obesity: a systematic review and pairwise and network meta-analysis of randomized controlled trials.European journal of medical research · 2026PMID 41582189Accessed 2 Oct 2026
  3. 3Retatrutide showing promise in obesity (and type 2 diabetes).Expert opinion on investigational drugs · 2023PMID 37947489Accessed 2 Oct 2026
  4. 4Retatrutide: a triple incretin receptor agonist for obesity management.Expert opinion on investigational drugs · 2023PMID 37902090Accessed 2 Oct 2026

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