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Does retatrutide lower cholesterol?

Yes. A meta-analysis found total cholesterol fell by a mean of 21.88 mg/dL, though trial results varied widely (I2 = 84%).

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

Yes. A meta-analysis found total cholesterol fell by a mean of 21.88 mg/dL, though trial results varied widely (I2 = 84%).[1]

Non-HDL cholesterol fell by up to 21.0% in one phase 2 dataset and up to 26.9% in the other.[2]

Which lipids moved and which did not

The meta-analysis found no significant effect on HDL cholesterol.[1]

Large triglyceride-rich lipoprotein particles fell by 84.4% and 76.6% in the two datasets.[2]

Falls in the ANGPTL3/8 protein complex ran in parallel with the triglyceride and LDL falls in blood samples from two earlier trials.[3]

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More on Retatrutide

ResultsStudy outcomes and when they were measured.Retatrutide overview

Sources

  1. 1Effect of Retatrutide, a Novel Triple Receptor Agonist, on Blood Pressure and Lipid Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026PMID 42371360Accessed 2 Oct 2026
  2. 2Retatrutide-Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes.Diabetes, obesity & metabolism · 2026PMID 42608321Accessed 2 Oct 2026
  3. 3Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids.Diabetes, obesity & metabolism · 2025PMID 40726454Accessed 2 Oct 2026

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