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Does retatrutide slow digestion?

In animal studies, retatrutide delayed gastric emptying, and a review links this to reduced food intake. These sources include no human gastric emptying measurement.

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

In animal studies, retatrutide delayed gastric emptying, and a review links this to reduced food intake. These sources include no human gastric emptying measurement.[1]

Digestive events recorded in trials

In the phase 2 obesity results, reflux disease was recorded for 1 of 70 placebo participants and 4 of 62 in the top-dose step-up arm, group EG006.[2]

Registry group EG006 in that obesity trial started at 2 mg and ended at 12 mg.[2]

In the same obesity results, abdominal distension affected 0 of 70 placebo participants and 5 of 62 in group EG006.[2]

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More on Retatrutide

How it worksTarget, mechanism and how long it acts, from the label or studies.Retatrutide overview

Sources

  1. 1Retatrutide-A Game Changer in Obesity Pharmacotherapy.Biomolecules · 2025PMID 40563436Accessed 2 Oct 2026
  2. 2A Phase 2 Study of Once-Weekly LY3437943 Compared With Placebo in Participants Who Have Obesity or Are Overweight With Weight-Related ComorbiditiesClinicalTrials.gov (U.S. National Library of Medicine) · 2021clinicaltrials.govAccessed 2 Oct 2026

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