Does retatrutide suppress appetite?
Yes, by self-report. In adults with diabetes, doses of 4 mg and above brought greater drops in overall appetite, hunger and expected food intake than placebo.
Short answer
Yes, by self-report. In adults with diabetes, doses of 4 mg and above brought greater drops in overall appetite, hunger and expected food intake than placebo.[1]
Against the comparator drug dulaglutide the appetite differences were less consistent.[1]
Registry counts of decreased appetite
In the obesity dose-finding registry, decreased appetite was logged in 6 of 70 on placebo and 18 of 62 in the top-dose step-up arm.[2]
In the diabetes dose-finding registry, it was logged in 0 of 45 on placebo and 9 of 46 in the top-dose step-up arm.[3]
Changes in hunger and overeating tracked weight change only moderately: the correlations were between 0.28 and 0.36.[1]
More questions on Retatrutide
More on Retatrutide
Sources
- 1Appetite, eating attitudes, and eating behaviours during treatment with retatrutide in adults with type 2 diabetes: Results of a phase 2 study.Diabetes, obesity & metabolism · 2025PMID 40916752Accessed 2 Oct 2026
- 2A Phase 2 Study of Once-Weekly LY3437943 Compared With Placebo in Participants Who Have Obesity or Are Overweight With Weight-Related ComorbiditiesClinicalTrials.gov (U.S. National Library of Medicine) · 2021clinicaltrials.govAccessed 2 Oct 2026
- 3A Phase 2 Study of Once-Weekly LY3437943 Compared With Placebo and Dulaglutide in Participants With Type 2 DiabetesClinicalTrials.gov (U.S. National Library of Medicine) · 2021clinicaltrials.govAccessed 2 Oct 2026
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