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How does retatrutide cause weight loss?

Retatrutide (code name LY3437943) acts on three receptors at once: glucagon, GIP and GLP-1.

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

Retatrutide (code name LY3437943) acts on three receptors at once: glucagon, GIP and GLP-1.[1]

In obese mice, the glucagon-receptor effect on energy expenditure was added to the calorie-reducing effect of the GIP and GLP-1 receptors; this is an animal finding.[1]

In adults with diabetes, higher retatrutide doses lowered self-reported hunger and tendency to overeat versus placebo, in an exploratory analysis.[2]

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More on Retatrutide

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Sources

  1. 1LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.Cell metabolism · 2022PMID 35985340Accessed 2 Oct 2026
  2. 2Appetite, eating attitudes, and eating behaviours during treatment with retatrutide in adults with type 2 diabetes: Results of a phase 2 study.Diabetes, obesity & metabolism · 2025PMID 40916752Accessed 2 Oct 2026

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