What does retatrutide do to your body?
The clearest effect is weight loss: in the obesity dose-finding trial, the 12 mg group lost 24.2% of body weight over 48 weeks against 2.1% on placebo.
Short answer
The clearest effect is weight loss: in the obesity dose-finding trial, the 12 mg group lost 24.2% of body weight over 48 weeks against 2.1% on placebo.[1]
Blood pressure, lipids and liver
A meta-analysis found systolic blood pressure fell by 6.79 mmHg and diastolic by 2.46 mmHg.[2]
The same meta-analysis found LDL cholesterol down by 13.10 mg/dL and triglycerides down by 40.90 mg/dL, with no significant change in HDL.[2]
In people with fatty liver disease, liver fat fell by 82.4% at 24 weeks on 12 mg, against a 0.3% rise on placebo.[3]
What it does on the other side
Gastrointestinal events were the most common side effects in the large obesity trial.[4]
Heart rate rose with dose in the dose-finding trial and then declined after week 24.[1]
More questions on Retatrutide
More on Retatrutide
Sources
- 1Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial.The New England journal of medicine · 2023PMID 37366315Accessed 2 Oct 2026
- 2Effect of Retatrutide, a Novel Triple Receptor Agonist, on Blood Pressure and Lipid Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026PMID 42371360Accessed 2 Oct 2026
- 3Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial.Nature medicine · 2024PMID 38858523Accessed 2 Oct 2026
- 4Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity.The New England journal of medicine · 2026PMID 42814954Accessed 2 Oct 2026
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