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Why am I hungry on retatrutide?

In adults with type 2 diabetes, perceived hunger and the tendency to overeat were reduced with higher doses compared with placebo, so hunger on retatrutide is not the typical trial result.

GLP-1 / GIP / glucagon triple agonistUpdated

Short answer

In adults with type 2 diabetes, perceived hunger and the tendency to overeat were reduced with higher doses compared with placebo, so hunger on retatrutide is not the typical trial result.[1]

What the sources show about appetite

Participants on the higher retatrutide doses reported lower appetite and hunger than on placebo, while differences against dulaglutide were less consistent.[1]

The improvements in perceived hunger and disinhibition were greater on 8 and 12 mg, which suggests lower doses may blunt hunger less.[1]

Hunger change tracked weight change: bigger weight loss went with lower perceived hunger and less overeating.[1]

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More on Retatrutide

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Sources

  1. 1Appetite, eating attitudes, and eating behaviours during treatment with retatrutide in adults with type 2 diabetes: Results of a phase 2 study.Diabetes, obesity & metabolism · 2025PMID 40916752Accessed 2 Oct 2026

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