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Does tesamorelin cause cancer?

The label warns of an increased risk of neoplasms and tells prescribers to weigh starting treatment against the higher background malignancy risk in HIV-positive patients.

GHRH analogUpdated

Short answer

The label warns of an increased risk of neoplasms and tells prescribers to weigh starting treatment against the higher background malignancy risk in HIV-positive patients.[1]

What the label says about malignancy

The label ties the caution to the way the drug works: it releases growth hormone, which it calls a known growth factor.[1]

For anyone whose cancer has returned during treatment, the label says to stop the drug.[1]

The label admits that the long-term effect of raised IGF-1 is unknown.[1]

In the 52-week trial data, 34% of patients had IGF-1 above 2 standard deviations and 23% above 3 at the end of treatment.[1]

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More on Tesamorelin

Side effectsWhat labels and studies report, and what is unknown.Tesamorelin overview

Sources

  1. 1EGRIFTA SV prescribing information (FDA label)FDA label, DailyMed · current labeldailymed.nlm.nih.govAccessed 2 Oct 2026

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