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Kisspeptin-10 Half-Life: How Long It Stays in Your System

How long Kisspeptin-10 stays in the body, how that shapes dosing frequency, and what is known about drug testing.

Medical review pendingGnRH stimulatorUpdated
Half-life
mean elimination half-life 1.3-2.2 hours
subcutaneous (analog MVT-602), in people · Fertility and sterility 2024, PMID 37925096
Dosing interval
Varies by study
as used in studies
WADA
Prohibited (S2.2.1)
In and out of competition
Detection window
2 findings
from anti-doping studies, below

Kisspeptin-10 half-life

A half-life depends on the route (under the skin, into a vein, by mouth or nasal spray) and the species it was measured in, so we report each value with its route and source.

Kisspeptin-10 half-life by route
RouteHalf-lifeMeasured inSource
subcutaneous (analog MVT-602)mean elimination half-life 1.3-2.2 hoursPeopleFertility and sterility 2024, PMID 37925096
subcutaneous (analog TAK-448)median terminal elimination half-life 1.4-5.3 hoursPeoplePMID 24762108

What half-life means

Half-life is the time it takes for the amount of a drug in the blood to fall by half. After one half-life, about 50% is left; after two, about 25%; after four to five, only a few percent remain.

  • A long half-life lets a drug be dosed less often, for example once a week.
  • A short half-life means levels rise and fall quickly, which is why some peptides are given daily or more often.
  • Effects can outlast blood levels, so half-life alone does not tell you how long a drug works.

What it means for dosing frequency

Dosing intervals used in published studies of Kisspeptin-10:

Changing the interval changes how much drug builds up between doses, so it is not a free choice.

Drug tests and sport

Prohibited by WADA (S2.2.1)

Kisspeptin and its agonist analogues are named in S2.2.1 (testosterone-stimulating peptides in males).

Detection findings from anti-doping analytical studies:

  • Kisspeptin-10 is cleared very fast (30 minutes in rats), so labs target metabolites. · PMID 38978171
  • A 2026 method detects kisspeptins in serum and urine; samples from people who actually took them were not yet tested. · PMID 42057309

Tested athletes should treat it as prohibited (s2.2.1) at all times.

What is cached for the native peptide

A doping-control paper notes that earlier research had shown a rapid elimination of kisspeptin-10, reported as 30 minutes in rats.[2]

Half-lives measured for analogs, which are different compounds

The analog MVT-602, studied in healthy premenopausal women, had a mean elimination half-life of 1.3 to 2.2 hours; this is not a kisspeptin value.[4]

The analog TAK-448, studied in healthy older subjects, had a median terminal half-life of 1.4 to 5.3 hours; this is not a kisspeptin value.[5]

Human pharmacokinetic records

A PubMed search on 2 Oct 2026 for kisspeptin with half-life or pharmacokinetic words in humans returned 13 records, and no native kisspeptin human half-life is cached on this site.

Calculated from source web/src/data/evidence/kisspeptin.json searches; date 2026-10-02; query kisspeptin[tiab] AND (half-life[tiab] OR pharmacokinetic*[tiab]) AND humans[mh]; count 13. Formula: count reported as recorded

Common questions

How long does Kisspeptin-10 stay in your system?

Its reported half-life is mean elimination half-life 1.3-2.2 hours (subcutaneous (analog MVT-602)); median terminal elimination half-life 1.4-5.3 hours (subcutaneous (analog TAK-448)). Most of a dose is gone after about four to five half-lives.

What is the half-life of Kisspeptin-10?

Mean elimination half-life 1.3-2.2 hours (subcutaneous (analog MVT-602)); median terminal elimination half-life 1.4-5.3 hours (subcutaneous (analog TAK-448)), from the sources cited below.

Is Kisspeptin-10 on the WADA prohibited list?

Yes. Prohibited by WADA (S2.2.1).

What is the half-life of kisspeptin?

The one native-peptide figure cached is a rat value cited in a doping-control paper.[2]

More on Kisspeptin-10

DosageDoses used in published studies, with the source for each.CalculatorVial, water and dose to syringe units.Side effectsWhat labels and studies report, and what is unknown.ResultsStudy outcomes and when they were measured.BenefitsClaimed benefits next to what published studies measured.How it worksTarget, mechanism and how long it acts, from the label or studies.

Sources

  1. 1World Anti-Doping Code International Standard Prohibited List 2026World Anti-Doping Agency · 2026wada-ama.orgAccessed 2 Oct 2026
  2. 2[Not Available].Biomedical chromatography : BMC · 2024PMID 38978171Accessed 2 Oct 2026
  3. 3Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.Drug testing and analysis · 2026PMID 42057309Accessed 2 Oct 2026
  4. 4Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricals.Fertility and sterility · 2024PMID 37925096Accessed 2 Oct 2026
  5. 5Sustained exposure to the investigational Kisspeptin analog, TAK-448, down-regulates testosterone into the castration range in healthy males and in patients with prostate cancer: results from two phase 1 studies.The Journal of clinical endocrinology and metabolism · 2014PMID 24762108Accessed 2 Oct 2026
  6. 6Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.European journal of endocrinology · 2026PMID 42549827Accessed 2 Oct 2026
  7. 7Acute and chronic effects of kisspeptin-54 administration on GH, prolactin and TSH secretion in healthy women.Clinical endocrinology · 2014PMID 24863252Accessed 2 Oct 2026
  8. 8Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis.The Journal of clinical endocrinology and metabolism · 2009PMID 19820030Accessed 2 Oct 2026

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