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MOTS-c for Liver: What the Evidence Shows

What human and animal studies show about MOTS-c for liver, how strong that evidence is, and what is still unproven.

Medical review pendingMitochondrial-derived peptideUpdated
Strongest evidence
None graded
no study with an outcome for liver (PubMed search, 11 Oct 2026)
Human studies
None found
with an outcome for liver, in our evidence file (PubMed search, 11 Oct 2026)
Animal studies
None found
with an outcome for liver, in our evidence file (PubMed search, 11 Oct 2026)

Evidence for liver

None of the study abstracts we summarised for MOTS-c reported an outcome for liver (PubMed search, 11 Oct 2026). Claims that it helps with liver are unproven.

How strong is it?

Strongest evidence:No graded study for liver (PubMed search, 11 Oct 2026)

A human randomized trial outweighs any number of animal studies. Animal and cell results show a mechanism worth testing, not that it works in people.

What liver means in the MOTS-c context

MedlinePlus says liver disease symptoms vary but often include swelling of the abdomen, and lists viruses, drugs, alcohol and inherited conditions among causes.[7]

How many MOTS-c papers mention liver

A PubMed title-and-abstract search pairing MOTS-c terms with liver terms returned 19 records on 2026-10-29. That is a keyword-match tally for MOTS-c and liver, not a count of positive findings.

Calculated from pubmed query ("MOTS-c"[tiab] OR MOTSc[tiab]) AND (liver[tiab] OR hepat*[tiab] OR steato*[tiab] OR NAFLD[tiab] OR NASH[tiab] OR MASLD[tiab] OR MASH[tiab] OR cirrho*[tiab]); date 2026-10-29; count 19. Formula: record count of the PubMed [tiab] query on the date shown, as logged by the literature ledger; no arithmetic

What the retrieved MOTS-c abstracts say about liver

In a hepatitis B study of healthy subjects and infected patients, MOTS-c levels correlated negatively with HBV DNA; a correlation of this kind does not show a treatment effect.[8]

In the same study's cell and mouse experiments, MOTS-c inhibited hepatitis B virus replication by 50-70% alongside improved liver function without notable toxicity; these are cell and animal results.[8]

In diet-induced obese mice, MOTS-c improved insulin sensitivity and increased fat burning to prevent fat accumulation, a mouse result about fat handling and not liver disease.[9]

A review of exercise-released molecules, MOTS-c among them, proposes that these exerkines may help regulate metabolism; it frames MOTS-c as a candidate and not a liver treatment.[10]

Other peptides people research for liver

RetatrutideTirzepatideSemaglutideBPC-157Kisspeptin-10TesamorelinHGHGHK-Cu
All peptides for liver, compared

Common questions

Does MOTS-c help with liver?

None of the studies we summarised for MOTS-c (PubMed search, 11 Oct 2026) measured an outcome for liver. Treat claims that it helps with liver as unproven.

Is MOTS-c approved for liver?

No. MOTS-c is not FDA approved for any use, including liver.

What is the best peptide for liver?

There is no single answer. Our liver overview compares each candidate by evidence grade and legal status rather than by popularity.

Is there research on MOTS-c and liver?

PubMed held 19 records matching the MOTS-c and liver search terms when checked on 2026-10-29; a match is not evidence that MOTS-c helps with liver.

Calculated from pubmed query ("MOTS-c"[tiab] OR MOTSc[tiab]) AND (liver[tiab] OR hepat*[tiab] OR steato*[tiab] OR NAFLD[tiab] OR NASH[tiab] OR MASLD[tiab] OR MASH[tiab] OR cirrho*[tiab]); date 2026-10-29; count 19. Formula: record count of the PubMed [tiab] query on the date shown, as logged by the literature ledger; no arithmetic

More on MOTS-c

DosageDoses used in published studies, with the source for each.CalculatorVial, water and dose to syringe units.Side effectsWhat labels and studies report, and what is unknown.ResultsStudy outcomes and when they were measured.BenefitsClaimed benefits next to what published studies measured.How it worksTarget, mechanism and how long it acts, from the label or studies.

Sources

  1. 1PubMed search: ("MOTS-c"[tiab] OR MOTSc[tiab]) (262 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  2. 2PubMed search: ("MOTS-c"[tiab] OR MOTSc[tiab]) AND (humans[mh] OR human[tiab] OR participants[tiab] OR patients[tiab] OR volunteers[tiab]) (179 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  3. 3PubMed search: ("MOTS-c"[tiab] OR MOTSc[tiab]) AND (randomized controlled trial[pt] OR "clinical trial"[pt] OR "meta-analysis"[pt] OR "systematic review"[pt]) (5 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  4. 4PubMed search: ("MOTS-c"[tiab] OR MOTSc[tiab]) AND (mice[tiab] OR mouse[tiab] OR rat[tiab] OR rats[tiab]) AND (injection[tiab] OR treatment[tiab] OR administration[tiab] OR treated[tiab]) (72 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  5. 5PubMed search: ("MOTS-c"[tiab] OR MOTSc[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (3 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  6. 6PubMed search: ("MOTS-c"[tiab] OR MOTSc[tiab] OR CB4211[tiab]) AND (adverse[tiab] OR "side effect*"[tiab] OR safety[tiab] OR tolerab*[tiab] OR toxicity[tiab] OR "case report"[pt]) (20 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 11 Oct 2026
  7. 7Official web pageOfficial web page · web page
  8. 8Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection.Gut · 2024PMID 37788894Accessed 2 Oct 2026
  9. 9The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity.Physiological reports · 2019PMID 31293078Accessed 29 Oct 2026
  10. 10Exercise and Metabolic Health: The Emerging Roles of Novel Exerkines.Current protein & peptide science · 2022PMID 35770405Accessed 2 Oct 2026

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