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Is tesamorelin a GLP-1?

No, the label classes tesamorelin as a growth hormone-releasing factor analogue indicated for excess abdominal fat in HIV-infected adults with lipodystrophy.

GHRH analogUpdated

Short answer

No, the label classes tesamorelin as a growth hormone-releasing factor analogue indicated for excess abdominal fat in HIV-infected adults with lipodystrophy.[1]

A different pathway

Its mechanism is on the pituitary: it stimulates release of growth hormone, which the label calls both anabolic and lipolytic.[1]

It is not approved for weight loss management, because overall weight stays about the same.[1]

A pooled analysis of four trials calls it a growth hormone-releasing hormone analogue and reports reduced visceral fat and higher lean mass.[2]

More questions on Tesamorelin

Can tesamorelin cause weight gain?Can women take tesamorelin?Does tesamorelin cause cancer?Does tesamorelin cause water retention?Does tesamorelin help build muscle?Does tesamorelin show up on a drug test?

More on Tesamorelin

How it worksTarget, mechanism and how long it acts, from the label or studies.Tesamorelin overview

Sources

  1. 1EGRIFTA SV prescribing information (FDA label)FDA label, DailyMed · current labeldailymed.nlm.nih.govAccessed 2 Oct 2026
  2. 2Efficacy and Safety of Tesamorelin in People Living With HIV (PLWH) With Lipodystrophy: A Systematic Review and Meta-Analysis.Journal of the International Association of Providers of AIDS Care · 2026PMID 42538058Accessed 2 Oct 2026

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