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What happens when you stop taking tesamorelin?

In the trial extension, visceral fat built back up once tesamorelin was stopped.

GHRH analogUpdated

Short answer

In the trial extension, visceral fat built back up once tesamorelin was stopped.[1]

What changes after stopping

In the extension study, patients switched from tesamorelin to placebo lost the gains in visceral fat quickly, while those who continued kept them.[2]

The label says fluid retention reactions such as edema and carpal tunnel syndrome are either transient or resolve after discontinuation.[3]

The label tells prescribers to consider discontinuing in patients with persistently high IGF-1 or no reduction in visceral fat.[3]

More questions on Tesamorelin

Can tesamorelin cause weight gain?Can women take tesamorelin?Does tesamorelin cause cancer?Does tesamorelin cause water retention?Does tesamorelin help build muscle?Does tesamorelin show up on a drug test?

More on Tesamorelin

ResultsStudy outcomes and when they were measured.Tesamorelin overview

Sources

  1. 1Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation.AIDS (London, England) · 2008PMID 18690162Accessed 2 Oct 2026
  2. 2Effects of tesamorelin, a growth hormone-releasing factor, in HIV-infected patients with abdominal fat accumulation: a randomized placebo-controlled trial with a safety extension.Journal of acquired immune deficiency syndromes (1999) · 2010PMID 20101189Accessed 2 Oct 2026
  3. 3EGRIFTA SV prescribing information (FDA label)FDA label, DailyMed · current labeldailymed.nlm.nih.govAccessed 2 Oct 2026

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