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Enclomiphene Side Effects: What Studies and Users Report

What FDA labels and clinical studies report for Enclomiphene, how strong that evidence is, and what is still unknown.

Medically reviewed by Juan Pablo Frías, MD · · DisclosureSERM (not a peptide)Updated

Side effects reported in studies

Side effects reported in published studies, strongest design first. Frequencies are quoted as the source gives them; animal results are labelled.

Side effects of Enclomiphene in labels and published studies
Side effectHow commonStudy typeSource
IGF-1 decrease“Both transdermal testosterone and enclomiphene citrate decreased IGF-1 levels (p<0.05) but suppression was greater in the enclomiphene citrate groups.”Frequency not statedHuman RCTn = 48BJU international 2013, PMID 23875626
Atrial flutter (causality only possible)“Formal causality assessment using the Naranjo scale placed the association in the possible category only.”Frequency not statedHuman case reportn = 1Cureus 2026, PMID 42741668
Fewer adverse effects than clomiphene“Adverse effects were statistically significantly less frequent with enclomiphene, including decreased libido (P=0.001), reduced energy (P=0.044), and mood changes (P=0.03).”Frequency not statedHuman observationaln = 66Translational andrology and urology 2024, PMID 39434750

What is not known

  • How common each effect is at the doses people use outside of studies.
  • Effects that take longer to appear than the length of the published studies.
  • How Enclomiphene interacts with other medicines and supplements.
  • Whether research-grade products, which are not checked by the FDA, behave like the material used in studies.

When to get medical help

Get urgent care for: trouble breathing, swelling of the face or throat, a widespread rash, severe or lasting stomach pain, fainting, or an injection site that becomes hot, red and spreading.

This is not a complete list. A doctor or pharmacist can help you judge whether a symptom is related.

Common questions

What are the side effects of Enclomiphene?

Studies we summarise reported igf-1 decrease, atrial flutter (causality only possible), fewer adverse effects than clomiphene. The table on this page gives how often each happened and links each source.

Is Enclomiphene safe?

Enclomiphene has an FDA-approved label that lists its known risks. That label covers the approved product used as prescribed, not compounded or research-chemical versions.

Is Enclomiphene banned in sport?

Yes. Prohibited by WADA (S4.2). Tested athletes should not use it.

More on Enclomiphene

DosageDoses used in published studies, with the source for each.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.Half-lifeWhat is measured, by route, and what is not.StoragePowder and mixed vials: temperature and shelf life.

Sources

  1. 1Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.BJU international · 2013PMID 23875626Accessed 2 Oct 2026
  2. 2Newly Detected Atrial Flutter After Enclomiphene Dose Escalation in a Patient With Prior Mitral Valve Repair and Chronic Immune Thrombocytopenia: A Case Report.Cureus · 2026PMID 42741668Accessed 2 Oct 2026
  3. 3Safety and efficacy of enclomiphene and clomiphene for hypogonadal men.Translational andrology and urology · 2024PMID 39434750Accessed 2 Oct 2026

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