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Enclomiphene Benefits: Claims vs What Studies Show

Benefits people claim for Enclomiphene, set against what published studies measured, and where no study exists.

Medical review pendingSERM (not a peptide)Updated
Strongest evidence
Human RCT
Human / animal studies
6 / 1
in our evidence file (PubMed search, 11 Oct 2026)
FDA status
Not approved
compounded

Claimed benefits and what studies show

Each row is an area where people claim a benefit, with the strongest study we summarise behind it. Animal and cell results are labelled and are not human results. User reports are not counted as evidence here.

Enclomiphene claimed benefits and the studies behind them
ClaimBest evidenceStudies (human / animal)What was measuredPage
TestosteroneHuman RCT evidence, 4 of 45 / 1Total testosterone; Sperm concentration vs gel; Testosterone, LH, spermEvidence for testosterone

Strongest study per claim: Testosterone, BJU international 2016, PMID 26496621.

What the studies measured

Enclomiphene outcomes in published studies
OutcomeResultStudy typeSource
Total testosteroneTotal testosterone rose from baseline at 16 weeks in all groups, including enclomiphene.Human RCTBJU international 2016, PMID 26496621
Sperm concentration vs gelSperm concentration stayed in the normal range with enclomiphene but fell markedly with testosterone gel.Human RCTBJU international 2016, PMID 26496621
Testosterone, LH, spermEnclomiphene raised morning testosterone, estradiol and LH similarly to topical gel; sperm counts conserved.Human RCTFertility and sterility 2014, PMID 25044085
Total testosterone at 6 monthsAt 6 months total testosterone was 545 (gel) and 525 (enclomiphene) pg/dL.Human RCTn = 12The journal of sexual medicine 2013, PMID 23530575
Sperm countsSperm counts rose in seven out of seven men at 3 months and six out of six men at 6 months on enclomiphene.Human RCTn = 12The journal of sexual medicine 2013, PMID 23530575
Total testosterone at day 42At 25 mg daily, day-42 testosterone averaged 604 ng/dL versus 500 ng for transdermal testosterone.Human RCTn = 48BJU international 2013, PMID 23875626
OnsetTestosterone increased within two weeks on enclomiphene.Human RCTn = 48BJU international 2013, PMID 23875626
Median testosterone changeMedian testosterone increase was 166 with enclomiphene versus 98 ng/dL with clomiphene (P=0.20, not significant).Human observationaln = 66Translational andrology and urology 2024, PMID 39434750
Total testosterone vs placeboSERMs (clomiphene or enclomiphene) raised total testosterone by a mean 273.76 ng/dL versus placebo, with high heterogeneity (I2 = 89%).Meta-analysisArchives of endocrinology and metabolism 2025, PMID 41066380
Versus T gelNo significant difference in total testosterone between SERMs and T gel.Meta-analysisArchives of endocrinology and metabolism 2025, PMID 41066380
Testosterone with enclomiphenePooled testosterone rose by a mean 7.50 nmol/L with enclomiphene (and 11.56 nmol/L with clomiphene).Meta-analysisn = 292Andrology 2023, PMID 36604313
Testicular effects of isomersIsolated enclomiphene raised testosterone production with no change in testicular histology in male mice.Animal · mouse (not a human result)BJU international 2016, PMID 26220499
Not shown in any study we cite. Searches behind this page: PubMed search on 2 Oct 2026 for “enclomiphene[tiab] OR enclomifene[tiab] OR "trans-clomiphene"[tiab]”: 98 results. PubMed search on 2 Oct 2026 for “(enclomiphene[tiab] OR enclomifene[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt])”: 9 results. PubMed search on 2 Oct 2026 for “(enclomiphene[tiab] OR enclomifene[tiab]) AND (hypogonadism[tiab] OR testosterone[tiab]) AND humans[mh]”: 17 results. PubMed search on 2 Oct 2026 for “(enclomiphene[tiab] OR enclomifene[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab])”: 5 results.

The testosterone claim

Claim: it raises testosterone. In two parallel phase III trials in overweight men with secondary hypogonadism, total testosterone rose over 16 weeks in all groups, including both enclomiphene doses.[1]

A phase II dosing study shows the effect size: mean total testosterone reached 604 ng/dL on the highest enclomiphene dose and 500 ng/dL on transdermal testosterone, not different from each other.[4]

A meta-analysis of randomised trials pooled clomiphene and enclomiphene as one SERM group and reports a mean difference in total testosterone of 273.76 ng/dL against placebo; it does not isolate enclomiphene.[6]

The fertility and sperm claim

Claim: it keeps sperm counts up while raising testosterone. In the phase III trials, enclomiphene kept sperm concentration in the normal range while the testosterone gel group showed a marked drop in spermatogenesis.[1]

In a small phase IIB study of men previously on topical testosterone, enclomiphene raised sperm counts in seven out of seven men at 3 months.[3]

Obesity-related low testosterone and side-effect claims

Claim: it works in men with obesity. A pooled analysis found a testosterone increase with enclomiphene of 7.50 nmol/L.[7]

Claim: fewer side effects than clomiphene. A retrospective review of 66 patients found significantly fewer adverse effects after switching to enclomiphene; it was not a randomised trial.[5]

Animal-only claim

Mouse data (animal only) found that the enclomiphene isomer had positive effects on testosterone production and no effects on testicular histology, while zuclomiphene did not.[8]

What no regulator has approved

The Drugs@FDA lookup of 2026-10-02 returned no match for enclomiphene, so none of these benefits is a labelled indication.[14]

More on Enclomiphene

DosageSide effectsResultsHow it works

Common questions

Is Enclomiphene proven to work?

The strongest study we summarise for Enclomiphene is human rct evidence, among 9 studies. A trial result is not an approval; see the legal status.

What is enclomiphene used for?

The studies cited test it in men with secondary hypogonadism, to raise testosterone without the suppression of sperm production seen with testosterone gel.[2]

More on Enclomiphene

DosageDoses used in published studies, with the source for each.Side effectsWhat labels and studies report, and what is unknown.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.How it worksTarget, mechanism and how long it acts, from the label or studies.

Sources

  1. 1Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.BJU international · 2016PMID 26496621Accessed 2 Oct 2026
  2. 2Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.Fertility and sterility · 2014PMID 25044085Accessed 2 Oct 2026
  3. 3Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.The journal of sexual medicine · 2013PMID 23530575Accessed 2 Oct 2026
  4. 4Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.BJU international · 2013PMID 23875626Accessed 2 Oct 2026
  5. 5Safety and efficacy of enclomiphene and clomiphene for hypogonadal men.Translational andrology and urology · 2024PMID 39434750Accessed 2 Oct 2026
  6. 6Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials.Archives of endocrinology and metabolism · 2025PMID 41066380Accessed 2 Oct 2026
  7. 7Selective modulation of estrogen receptor in obese men with androgen deficiency: A systematic review and meta-analysis.Andrology · 2023PMID 36604313Accessed 2 Oct 2026
  8. 8Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice.BJU international · 2016PMID 26220499Accessed 2 Oct 2026
  9. 9PubMed search: enclomiphene[tiab] OR enclomifene[tiab] OR "trans-clomiphene"[tiab] (98 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  10. 10PubMed search: (enclomiphene[tiab] OR enclomifene[tiab]) AND (randomized controlled trial[pt] OR clinical trial[pt] OR meta-analysis[pt]) (9 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  11. 11PubMed search: (enclomiphene[tiab] OR enclomifene[tiab]) AND (hypogonadism[tiab] OR testosterone[tiab]) AND humans[mh] (17 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  12. 12PubMed search: (enclomiphene[tiab] OR enclomifene[tiab]) AND (half-life[tiab] OR pharmacokinetic*[tiab]) (5 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 2 Oct 2026
  13. 13PubMed search: enclomiphene[tiab] OR enclomifene[tiab] OR Androxal[tiab] AND (adverse[tiab] OR "side effect*"[tiab] OR safety[tiab] OR tolerab*[tiab] OR toxicity[tiab] OR "case report"[pt]) (17 results)PubMed · 2026pubmed.ncbi.nlm.nih.govAccessed 11 Oct 2026
  14. 14Drugs@FDA (openFDA) search: active ingredient "enclomiphene"U.S. Food and Drug Administration · 2026api.fda.govAccessed 2 Oct 2026

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