Enclomiphene for Testosterone: What the Evidence Shows
What human and animal studies show about Enclomiphene for testosterone, how strong that evidence is, and what is still unproven.
- Strongest evidence
- Human RCT
- Human studies
- 14
- PubMed records, our ledger
- Animal studies
- 5
- PubMed records, our ledger
- Studies we summarised
- 8
- with an outcome for testosterone
Evidence for testosterone
Each row is an outcome related to testosterone from a published study, strongest design first. Animal and cell results are labelled and are not human results. User reports are not counted as evidence here.
| Outcome | Result | Study type | Source |
|---|---|---|---|
| Total testosterone | Total testosterone rose from baseline at 16 weeks in all groups, including enclomiphene. | Human RCT | BJU international 2016, PMID 26496621 |
| Sperm concentration vs gel | Sperm concentration stayed in the normal range with enclomiphene but fell markedly with testosterone gel. | Human RCT | BJU international 2016, PMID 26496621 |
| Testosterone, LH, sperm | Enclomiphene raised morning testosterone, estradiol and LH similarly to topical gel; sperm counts conserved. | Human RCT | Fertility and sterility 2014, PMID 25044085 |
| Total testosterone at 6 months | At 6 months total testosterone was 545 (gel) and 525 (enclomiphene) pg/dL. | Human RCTn = 12 | The journal of sexual medicine 2013, PMID 23530575 |
| Sperm counts | Sperm counts rose in seven out of seven men at 3 months and six out of six men at 6 months on enclomiphene. | Human RCTn = 12 | The journal of sexual medicine 2013, PMID 23530575 |
| Total testosterone at day 42 | At 25 mg daily, day-42 testosterone averaged 604 ng/dL versus 500 ng for transdermal testosterone. | Human RCTn = 48 | BJU international 2013, PMID 23875626 |
| Onset | Testosterone increased within two weeks on enclomiphene. | Human RCTn = 48 | BJU international 2013, PMID 23875626 |
| Median testosterone change | Median testosterone increase was 166 with enclomiphene versus 98 ng/dL with clomiphene (P=0.20, not significant). | Human observationaln = 66 | Translational andrology and urology 2024, PMID 39434750 |
| Total testosterone vs placebo | SERMs (clomiphene or enclomiphene) raised total testosterone by a mean 273.76 ng/dL versus placebo, with high heterogeneity (I2 = 89%). | Meta-analysis | Archives of endocrinology and metabolism 2025, PMID 41066380 |
| Versus T gel | No significant difference in total testosterone between SERMs and T gel. | Meta-analysis | Archives of endocrinology and metabolism 2025, PMID 41066380 |
| Testosterone with enclomiphene | Pooled testosterone rose by a mean 7.50 nmol/L with enclomiphene (and 11.56 nmol/L with clomiphene). | Meta-analysisn = 292 | Andrology 2023, PMID 36604313 |
| Testicular effects of isomers | Isolated enclomiphene raised testosterone production with no change in testicular histology in male mice. | Animal · mouse (not a human result) | BJU international 2016, PMID 26220499 |
PubMed records for Enclomiphene and testosterone: 14 human, 5 animal (search counts, not studies we reviewed). Grades follow our evidence scale.
How strong is it?
A human randomized trial outweighs any number of animal studies. Animal and cell results show a mechanism worth testing, not that it works in people.
Other peptides people research for testosterone
All peptides for testosterone, comparedCommon questions
Does Enclomiphene help with testosterone?
The strongest study we summarise for testosterone is human rct evidence, across 8 studies with an outcome for testosterone. A trial result is not an approval; see the legal status.
Is Enclomiphene approved for testosterone?
Enclomiphene is Not FDA approved · compounded. Which conditions that approval covers is set by the label; use for anything else is off-label.
What is the best peptide for testosterone?
There is no single answer. Our testosterone overview compares each candidate by evidence grade and legal status rather than by popularity.
More on Enclomiphene
DosageDoses used in published studies, with the source for each.Side effectsWhat labels and studies report, and what is unknown.ResultsStudy outcomes and when they were measured.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.Half-lifeWhat is measured, by route, and what is not.
Sources
- 1Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.BJU international · 2016PMID 26496621Accessed 2 Oct 2026
- 2Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.Fertility and sterility · 2014PMID 25044085Accessed 2 Oct 2026
- 3Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.The journal of sexual medicine · 2013PMID 23530575Accessed 2 Oct 2026
- 4Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.BJU international · 2013PMID 23875626Accessed 2 Oct 2026
- 5Safety and efficacy of enclomiphene and clomiphene for hypogonadal men.Translational andrology and urology · 2024PMID 39434750Accessed 2 Oct 2026
- 6Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials.Archives of endocrinology and metabolism · 2025PMID 41066380Accessed 2 Oct 2026
- 7Selective modulation of estrogen receptor in obese men with androgen deficiency: A systematic review and meta-analysis.Andrology · 2023PMID 36604313Accessed 2 Oct 2026
- 8Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice.BJU international · 2016PMID 26220499Accessed 2 Oct 2026
Found an error? Report a correction.