What does kisspeptin do for men?
In healthy men, a 22.5-hour kisspeptin-10 infusion raised LH from a mean of 5.4 to 20.8 IU/liter and testosterone from 16.6 to 24.0 nmol/liter.
Short answer
In healthy men, a 22.5-hour kisspeptin-10 infusion raised LH from a mean of 5.4 to 20.8 IU/liter and testosterone from 16.6 to 24.0 nmol/liter.[1]
Continuous infusion did not keep gonadotropins up: after 5 days they were similar to vehicle, while testosterone stayed elevated.[2]
Other measured effects
Daily 8-hour infusions over 12 days sustained increased gonadotropins.[2]
In healthy men, kisspeptin administration raised a bone-formation marker (total osteocalcin) by a maximum of 20.3%.[3]
Kisspeptin-10 stimulated gonadotropin release in men and in women during the preovulatory phase, in a small mixed-sex study.[4]
More questions on Kisspeptin-10
More on Kisspeptin-10
Sources
- 1Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.The Journal of clinical endocrinology and metabolism · 2011PMID 21632807Accessed 2 Oct 2026
- 2Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.European journal of endocrinology · 2026PMID 42549827Accessed 2 Oct 2026
- 3Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men.The Journal of clinical endocrinology and metabolism · 2022PMID 35244717Accessed 2 Oct 2026
- 4The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans.The Journal of clinical endocrinology and metabolism · 2011PMID 21976724Accessed 2 Oct 2026
Found an error? Report a correction.