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What does kisspeptin do for women?

In healthy women given kisspeptin-54, the effect on LH release was greatest in the preovulatory phase of the cycle and least in the follicular phase.

GnRH stimulatorUpdated

Short answer

In healthy women given kisspeptin-54, the effect on LH release was greatest in the preovulatory phase of the cycle and least in the follicular phase.[1]

Twice-weekly kisspeptin-54 injections for 8 weeks raised reproductive hormone levels in women with hypothalamic amenorrhea compared with saline.[2]

Other findings in women

With repeated daily dosing the response shrank: by the 14th injection day the rise in LH was much smaller than at the start.[3]

Kisspeptin-54 used as the trigger for egg maturation in women having IVF led to a clinical pregnancy rate of 23% (12 of 53).[4]

In women with low sexual desire disorder, kisspeptin changed brain responses to sexual and facial attraction cues and was well tolerated in that study.[5]

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Sources

  1. 1Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women.The Journal of clinical endocrinology and metabolism · 2007PMID 17635940Accessed 2 Oct 2026
  2. 2Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea.Clinical pharmacology and therapeutics · 2010PMID 20980998Accessed 2 Oct 2026
  3. 3Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis.The Journal of clinical endocrinology and metabolism · 2009PMID 19820030Accessed 2 Oct 2026
  4. 4Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.The Journal of clinical investigation · 2014PMID 25036713Accessed 2 Oct 2026
  5. 5Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.JAMA network open · 2022PMID 36287566Accessed 2 Oct 2026

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