BPC-157 Oral (Pills and Capsules): What Studies Show
Which studies gave BPC-157 as a oral form, what they measured, and what is approved. No product recommendations.
- Route
- oral
- FDA-approved product for this route
- None
- Route studies (human / animal)
- 0 / 5
- in our evidence file (PubMed search, 11 Oct 2026)
Studies that gave BPC-157 oral
Each row is a study whose stated route matches. Animal and cell results are labelled and are not human results.
| Study | Design | n | Dose | First outcome |
|---|---|---|---|---|
| Life sciences 2022, PMID 36228773 | Animal · mouse (plus rat liver cell line) (not a human result) | Not stated | Not stated | Radiation-induced liver injury: Oral BPC 157 reduced radiation-induced liver injury, lowering plasma AST and ALT in mice. |
| Biomedicines 2021, PMID 35052769 | Animal · rat (not a human result) | Not stated | 0.4 ug/eye, 0.4 ng/eye; 10 ug/kg, 10 ng/kg | Intraocular pressure: All BPC 157 regimens (eye drops, intraperitoneal, oral) normalized intraocular pressure in this rat glaucoma model. |
| Journal of physiology and pharmacology 2013, PMID 24304574 | Animal · rat (not a human result) | Not stated | 10 ug/kg or 10 ng/kg | Colitis and anastomosis healing: Control rats did not heal; BPC 157 induced healing of both cysteamine colitis and colon-colon anastomosis. |
| Journal of orthopaedic research 2010, PMID 20225319 | Animal · rat (not a human result) | Not stated | 10 microg or 10 ng/kg i.p.; 1.0 microg/g cream topically; 0.16 microg/ml in drinking water | Ligament healing: BPC 157-treated rats showed consistent functional, biomechanical, macroscopic and histological healing improvements. |
| Journal of pharmacological sciences 2008, PMID 18818478 | Animal · rat (not a human result) | Not stated | 10 microg/kg, 10 ng/kg | Fistula healing: BPC 157 given by injection or by mouth accelerated healing of the colon and skin defects and closed the fistula. |
For the injected form, see BPC-157 how to inject and BPC-157 half-life.
Every oral-route BPC-157 study in the cache is in animals
In rat ligament healing, the oral arm was BPC-157 in drinking water at 0.16 microg/ml, alongside injected and cream arms.[4]
In rat colitis and anastomosis, one arm took the peptide in drinking water and was compared with saline-treated controls.[3]
In a rat colon-to-skin fistula model, healing was reported for both injected and by-mouth dosing.[5]
In mice given a single 12 Gy radiation dose, the peptide was given by mouth and lowered plasma liver enzymes.[1]
In a rat glaucoma experiment the drinking-water regimen started with an intragastric first dose.[2]
What the data say about swallowing versus injecting
The only direct route comparison in the cache is a rat ulcer study, which found intramuscular dosing better than intragastric.[6]
Of the 5 oral-route studies cached, 5 are in rats or mice and 0 are in people; no capsule, tablet or pill was studied in any of them.
Calculated from oral route studies 5; in rodents 5; in humans 0; source cached abstracts 20225319, 24304574, 18818478, 36228773, 35052769. Formula: humans = oralRouteStudies - inRodents = 5 - 5
A systematic review lists no oral human outcome and states there are no clinical safety data.[7]
Common questions
Is there an FDA-approved oral form of BPC-157?
We found no FDA-approved oral product for BPC-157 in our evidence file. Products sold as oral forms are not checked by the FDA.
Have studies given BPC-157 as a oral form?
5 studies in our evidence file gave BPC-157 by a oral route: 0 in people and 5 in animals.
Does BPC-157 work in capsules or pills?
None of the oral studies tested a capsule; the routes were drinking water or tube feeding in animals, and the review found only 1 clinical study overall.[7]
Is oral BPC-157 FDA approved?
The systematic review states that the peptide lacks FDA approval.[7]
More on BPC-157
Sources
- 1Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro.Life sciences · 2022PMID 36228773Accessed 2 Oct 2026
- 2Stable Gastric Pentadecapeptide BPC 157 Therapy of Rat Glaucoma.Biomedicines · 2021PMID 35052769Accessed 2 Oct 2026
- 3Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2013PMID 24304574Accessed 2 Oct 2026
- 4Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2010PMID 20225319Accessed 2 Oct 2026
- 5Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system.Journal of pharmacological sciences · 2008PMID 18818478Accessed 2 Oct 2026
- 6Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats.World journal of gastroenterology · 2004PMID 15052688Accessed 2 Oct 2026
- 7Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025PMID 40756949Accessed 2 Oct 2026
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