BPC-157 Results: What Studies Measured and When
What published studies measured for BPC-157, when those outcomes were measured, and what is still unproven.
What studies measured
Each outcome below comes from a published study, with its type and size, strongest design first. Animal and cell results are labelled as such and are not human results.
| Outcome | Result | Study type | Source |
|---|---|---|---|
| Safety biomarkers after IV infusion | No measurable change in the tested heart, liver, kidney, thyroid or glucose biomarkers (very small pilot). | Human uncontrolled trialn = 2 | Alternative therapies in health and medicine 2025, PMID 40131143 |
| Interstitial cystitis symptoms | 10 of 12 patients reported complete symptom resolution after one treatment on a patient-rated scale. No control group. | Human uncontrolled trialn = 12 | Alternative therapies in health and medicine 2024, PMID 39325560 |
| Knee pain relief (BPC 157 alone) | 11 of 12 patients who received the peptide alone (91.6%) reported significant improvement; 1 (8.3%) reported none. Self-reported by phone, no control group. | Human observationaln = 17 | Alternative therapies in health and medicine 2021, PMID 34324435 |
| Knee pain relief (overall) | 14 of 16 patients (87.5%) reported relief with BPC 157 alone or combined with thymosin beta-4 (TB4). | Human observationaln = 17 | Alternative therapies in health and medicine 2021, PMID 34324435 |
| Evidence base size | Only 1 of 36 included studies was clinical; 35 were preclinical. | Systematic review | HSS journal 2025, PMID 40756949 |
| Musculoskeletal outcomes in preclinical models | Preclinical models showed improved outcomes in muscle, tendon, ligament and bone injury. | Systematic review | HSS journal 2025, PMID 40756949 |
| Human safety data | The review found no clinical safety data. | Systematic review | HSS journal 2025, PMID 40756949 |
| Maximum load to failure (BPC-157) | Maximum load to failure was higher with BPC-157 than controls, but the difference was significant only in the TB-500 group (p < 0.05). | Animal · rat (not a human result)n = 32 | Joint diseases and related surgery 2026, PMID 42542926 |
| Tendon histology (BPC-157) | BPC-157 alone gave numerically lower tendon degeneration scores that did not reach statistical significance. | Animal · rat (not a human result)n = 32 | Joint diseases and related surgery 2026, PMID 42542926 |
| Incisional pain | BPC-157 reduced incisional pain behaviour only briefly in rats; effect was not sustained. | Animal · rat (not a human result) | Journal of dental anesthesia and pain medicine 2022, PMID 35449779 |
| Radiation-induced liver injury | Oral BPC 157 reduced radiation-induced liver injury, lowering plasma AST and ALT in mice. | Animal · mouse (plus rat liver cell line) (not a human result) | Life sciences 2022, PMID 36228773 |
| Myocardial infarction markers | BPC 157 reduced cardiac necrosis markers and attenuated gross, histological, ECG and echocardiographic damage in rats given isoprenaline. | Animal · rat (not a human result) | Biomedicines 2022, PMID 35203478 |
| Elimination half-life | Elimination half-life of BPC157 was under 30 minutes in rats and beagle dogs, with linear pharmacokinetics. | Animal · rat, beagle dog (not a human result) | Frontiers in pharmacology 2022, PMID 36588717 |
| Bioavailability after IM injection | Intramuscular bioavailability was approximately 14%-19% in rats and 45%-51% in beagle dogs. | Animal · rat, beagle dog (not a human result) | Frontiers in pharmacology 2022, PMID 36588717 |
| Intraocular pressure | All BPC 157 regimens (eye drops, intraperitoneal, oral) normalized intraocular pressure in this rat glaucoma model. | Animal · rat (not a human result) | Biomedicines 2021, PMID 35052769 |
| Spinal cord injury recovery | Rats treated with BPC 157 after spinal cord injury showed clinical improvement, better tail motor function and resolved spasticity by day 15. | Animal · rat (not a human result) | Journal of orthopaedic surgery and research 2019, PMID 31266512 |
| Ischemic colon blood supply | In rats with ischemic colitis, BPC 157 restored blood supply to the injured colon and activated collateral vessels. | Animal · rat (not a human result) | World journal of gastroenterology 2017, PMID 29358856 |
| Colitis and anastomosis healing | Control rats did not heal; BPC 157 induced healing of both cysteamine colitis and colon-colon anastomosis. | Animal · rat (not a human result) | Journal of physiology and pharmacology 2013, PMID 24304574 |
| Ligament healing | BPC 157-treated rats showed consistent functional, biomechanical, macroscopic and histological healing improvements. | Animal · rat (not a human result) | Journal of orthopaedic research 2010, PMID 20225319 |
| Muscle healing despite corticosteroid | BPC 157 reversed the corticosteroid-impaired muscle healing in this rat injury model. | Animal · rat (not a human result) | Medical science monitor 2010, PMID 20190676 |
| Sciatic nerve healing | BPC 157 improved nerve regeneration, motor action potentials and walking recovery after sciatic nerve transection in rats. | Animal · rat (not a human result) | Regulatory peptides 2010, PMID 19903499 |
| Periodontal inflammation | BPC 157 treatment significantly reduced plasma extravasation, histological inflammation and alveolar bone resorption in ligature periodontitis. | Animal · rat (not a human result) | Journal of physiology and pharmacology 2009, PMID 20388954 |
| Fistula healing | BPC 157 given by injection or by mouth accelerated healing of the colon and skin defects and closed the fistula. | Animal · rat (not a human result) | Journal of pharmacological sciences 2008, PMID 18818478 |
| Laser wound healing | Topical BPC 157 cream improved healing of laser skin injuries macroscopically and microscopically. | Animal · mouse (not a human result) | Burns 2005, PMID 15774286 |
| Gastric ulcer | BPC 157 given intramuscularly or intragastrically reduced ulcer area and accelerated ulcer healing in rats; intramuscular dosing was better than intragastric. | Animal · rat (not a human result) | World journal of gastroenterology 2004, PMID 15052688 |
| Achilles tendon healing | Control rats had severely compromised healing; BPC 157-treated rats recovered better on biomechanical, functional, microscopic and macroscopic measures. | Animal · rat (not a human result) | Journal of orthopaedic research 2003, PMID 14554208 |
| Biomechanics | Increased load of failure and Young's modulus of elasticity. | Animal · rat (not a human result) | Journal of orthopaedic research 2003, PMID 14554208 |
| Burn wound healing | BPC 157 cream-treated mice had improved burn healing parameters throughout the experiment compared with untreated controls. | Animal · mouse (not a human result) | Burns 2001, PMID 11718984 |
| Re-epithelization | Two weeks after injury, BPC 157 cream reversed the poor re-epithelization seen in untreated and vehicle-only mice. | Animal · mouse (not a human result) | Burns 2001, PMID 11718984 |
| Segmental bone defect healing | BPC-157 significantly improved healing of the segmental bone defect, comparable to bone marrow or autologous cortical graft. | Animal · rabbit (not a human result) | Bone 1999, PMID 10071911 |
Showing the first 30 of 31 rows, strongest sources first.
- Human evidence is very small: 3 uncontrolled clinical reports (knee-pain chart review n=17, interstitial cystitis pilot n=12, IV safety pilot n=2) from private clinics, all in one journal, none randomized or controlled. A 2025 systematic review found 1 clinical study among 36 included.
- Nearly all efficacy evidence is in rats, mice and rabbits. Animal results do not establish effects or safe doses in people.
- The 2025 systematic review (PMID 40756949) reported "No clinical safety data were found"; the only human safety report found here involves 2 participants.
- The knee-pain count differs between sources: the original study reports 11 of 12 improved on BPC 157 alone; the systematic review summarises it as "7 of 12 patients reported relief for >6 months". The original study's figure is used here.
- No randomized controlled trial of BPC-157 has been published in PubMed as of 2 October 2026.
- No evidence was found in the selected studies for hair growth, sleep, energy, wrinkles, skin tightening, cellulite, psoriasis, eczema, allergies, fibromyalgia, back pain, shoulder pain, blood pressure, osteoporosis, rheumatoid arthritis, immune system, longevity or menopause.
Typical timeline
When the studies above measured their outcomes. This is the study schedule, not a promise of when anyone will notice a change.
| When | What was measured | Study type | Source |
|---|---|---|---|
| Most patients 6 months to 1 year after injection | Follow-up survey | Human observationaln = 17 | Alternative therapies in health and medicine 2021, PMID 34324435 |
| 0, 2, 6 h and 4, 7 d after incision | Von Frey withdrawal responses | Animal · rat (not a human result) | Journal of dental anesthesia and pain medicine 2022, PMID 35449779 |
| Days 1, 4, 7, 10 and 14 | Biomechanical, microscopical and macroscopical assessment | Animal · rat (not a human result) | Journal of orthopaedic research 2003, PMID 14554208 |
Before-and-after photos
We don't publish before-and-after photos. They can't be verified, rarely show dose, diet or other drugs, and only the most dramatic results get posted.
Common questions
How long does BPC-157 take to work?
The studies we summarise measured outcomes at set points, for example Follow-up survey at Most patients 6 months to 1 year after injection; Von Frey withdrawal responses at 0, 2, 6 h and 4, 7 d after incision. Timelines outside studies vary.
Do you show BPC-157 before and after photos?
No. Photos can't be verified, rarely show dose, diet or other drugs, and only the most dramatic ones get posted. We summarize measured outcomes instead.
More on BPC-157
DosageDoses used in published studies, with the source for each.CalculatorVial, water and dose to syringe units.Side effectsWhat labels and studies report, and what is unknown.PricePrice per mg and per week from dated listings. No vendor links.Legal statusFDA, compounding and WADA status with dates.How to injectSites, syringe types and hygiene, step by step.
Sources
- 1Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.Alternative therapies in health and medicine · 2025PMID 40131143Accessed 2 Oct 2026
- 2Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study.Alternative therapies in health and medicine · 2024PMID 39325560Accessed 2 Oct 2026
- 3Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain.Alternative therapies in health and medicine · 2021PMID 34324435Accessed 2 Oct 2026
- 4Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025PMID 40756949Accessed 2 Oct 2026
- 5Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.Joint diseases and related surgery · 2026PMID 42542926Accessed 2 Oct 2026
- 6The anti-nociceptive effect of BPC-157 on the incisional pain model in rats.Journal of dental anesthesia and pain medicine · 2022PMID 35449779Accessed 2 Oct 2026
- 7Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro.Life sciences · 2022PMID 36228773Accessed 2 Oct 2026
- 8Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats.Biomedicines · 2022PMID 35203478Accessed 2 Oct 2026
- 9Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs.Frontiers in pharmacology · 2022PMID 36588717Accessed 2 Oct 2026
- 10Stable Gastric Pentadecapeptide BPC 157 Therapy of Rat Glaucoma.Biomedicines · 2021PMID 35052769Accessed 2 Oct 2026
- 11Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats.Journal of orthopaedic surgery and research · 2019PMID 31266512Accessed 2 Oct 2026
- 12Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights.World journal of gastroenterology · 2017PMID 29358856Accessed 2 Oct 2026
- 13Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2013PMID 24304574Accessed 2 Oct 2026
- 14Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2010PMID 20225319Accessed 2 Oct 2026
- 15Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application.Medical science monitor : international medical journal of experimental and clinical research · 2010PMID 20190676Accessed 2 Oct 2026
- 16Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury.Regulatory peptides · 2010PMID 19903499Accessed 2 Oct 2026
- 17Antiinflammatory effect of BPC 157 on experimental periodontitis in rats.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2009PMID 20388954Accessed 2 Oct 2026
- 18Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system.Journal of pharmacological sciences · 2008PMID 18818478Accessed 2 Oct 2026
- 19The stable gastric pentadecapeptide BPC 157, given locally, improves CO2 laser healing in mice.Burns : journal of the International Society for Burn Injuries · 2005PMID 15774286Accessed 2 Oct 2026
- 20Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats.World journal of gastroenterology · 2004PMID 15052688Accessed 2 Oct 2026
- 21Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2003PMID 14554208Accessed 2 Oct 2026
- 22Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice.Burns : journal of the International Society for Burn Injuries · 2001PMID 11718984Accessed 2 Oct 2026
- 23Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation.Bone · 1999PMID 10071911Accessed 2 Oct 2026
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