Skip to content
Peptigraph home
Shop Peptides50% off*

Does enclomiphene build muscle?

Muscle gain is not shown: the phase II trial's main outcome measures were hormone levels and semen analysis, not muscle, lean mass or strength.

SERM (not a peptide)Updated

Short answer

Muscle gain is not shown: the phase II trial's main outcome measures were hormone levels and semen analysis, not muscle, lean mass or strength.[1]

What the phase III studies did show is a rise in total testosterone over 16 weeks. A hormone level is not a muscle outcome, and these studies did not link the two.[2]

A hormone that moved the other way

IGF-1, a growth-related hormone, went down in a phase II trial and fell more in the enclomiphene groups than with testosterone gel; the trial did not connect that change to muscle.[3]

More questions on Enclomiphene

Does enclomiphene increase libido?Does enclomiphene increase testicle size?Does enclomiphene lower IGF-1?Does enclomiphene raise estrogen?Does enclomiphene work?How long does enclomiphene take to work?

More on Enclomiphene

ResultsStudy outcomes and when they were measured.Enclomiphene overview

Sources

  1. 1Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.Fertility and sterility · 2014PMID 25044085Accessed 2 Oct 2026
  2. 2Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.BJU international · 2016PMID 26496621Accessed 2 Oct 2026
  3. 3Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.BJU international · 2013PMID 23875626Accessed 2 Oct 2026

Found an error? Report a correction.