Does enclomiphene increase testicle size?
No cached trial reports testicles getting larger; a review says enclomiphene may maintain testicular volume while restoring testosterone.
SERM (not a peptide)Updated
Short answer
No cached trial reports testicles getting larger; a review says enclomiphene may maintain testicular volume while restoring testosterone.[1]
Sperm and testis findings
In two phase III studies, sperm concentration stayed in the normal range on enclomiphene, while the testosterone gel group saw a marked reduction.[2]
In a small trial every man tested had higher sperm counts on enclomiphene at both timepoints.[3]
In male mice given the isolated enclomiphene isomer for a long period, testicular histology was unchanged (animal data).[4]
More questions on Enclomiphene
More on Enclomiphene
Sources
- 1Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men.IDrugs : the investigational drugs journal · 2009PMID 19204885Accessed 11 Oct 2026
- 2Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.BJU international · 2016PMID 26496621Accessed 2 Oct 2026
- 3Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.The journal of sexual medicine · 2013PMID 23530575Accessed 2 Oct 2026
- 4Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice.BJU international · 2016PMID 26220499Accessed 2 Oct 2026
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