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How long does enclomiphene take to work?

For the testosterone blood level, a phase II trial reported a rise within a fortnight.

SERM (not a peptide)Updated

Short answer

For the testosterone blood level, a phase II trial reported a rise within a fortnight.[1]

A separate trial reported testosterone at a similar level on enclomiphene and on gel at 6 months, with wide spread between men (the source gives pg/dL, as printed).[2]

How long studies ran

The studies pooled in a meta-analysis ran for 1.5-4 months, so the timing data stop at about four months.[3]

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More on Enclomiphene

ResultsStudy outcomes and when they were measured.Enclomiphene overview

Sources

  1. 1Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.BJU international · 2013PMID 23875626Accessed 2 Oct 2026
  2. 2Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.The journal of sexual medicine · 2013PMID 23530575Accessed 2 Oct 2026
  3. 3Selective modulation of estrogen receptor in obese men with androgen deficiency: A systematic review and meta-analysis.Andrology · 2023PMID 36604313Accessed 2 Oct 2026

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