Does enclomiphene lower IGF-1?
In one phase II trial in men with secondary hypogonadism, enclomiphene lowered IGF-1, and the drop was bigger than with transdermal testosterone.
SERM (not a peptide)Updated
Short answer
In one phase II trial in men with secondary hypogonadism, enclomiphene lowered IGF-1, and the drop was bigger than with transdermal testosterone.[1]
What the trial and related work reported
The comparison came from a randomised phase II study giving three enclomiphene doses against a testosterone gel, and the abstract does not say whether the IGF-1 change mattered clinically.[1]
Other measures in the same trial did not move significantly, including TSH, ACTH, cortisol, lipids and bone markers.[1]
A separate 12-man phase IIB trial also measured IGF-1 but its abstract reports no IGF-1 result.[2]
More questions on Enclomiphene
More on Enclomiphene
Sources
- 1Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.BJU international · 2013PMID 23875626Accessed 2 Oct 2026
- 2Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.The journal of sexual medicine · 2013PMID 23530575Accessed 2 Oct 2026
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