Does enclomiphene raise estrogen?
Yes, in one phase II trial: morning estradiol (E2) rose along with testosterone and LH, at levels similar to those seen with testosterone gel.
SERM (not a peptide)Updated
Short answer
Yes, in one phase II trial: morning estradiol (E2) rose along with testosterone and LH, at levels similar to those seen with testosterone gel.[1]
In a retrospective study of men switched from clomiphene to enclomiphene, the estradiol change on enclomiphene was lower than on clomiphene (-5.92 versus 17.50 pg/mL), which is an association from a small single-centre review.[2]
Why estradiol can move
The drug blocks the estradiol receptor in the hypothalamus rather than lowering estradiol itself, so blood estradiol and receptor activity are separate questions.[3]
More questions on Enclomiphene
More on Enclomiphene
Sources
- 1Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.Fertility and sterility · 2014PMID 25044085Accessed 2 Oct 2026
- 2Safety and efficacy of enclomiphene and clomiphene for hypogonadal men.Translational andrology and urology · 2024PMID 39434750Accessed 2 Oct 2026
- 3Minimal ovarian stimulation with clomiphene citrate: a large-scale retrospective study.Reproductive biomedicine online · 2007PMID 17697488Accessed 2 Oct 2026
Found an error? Report a correction.