Does enclomiphene increase libido?
No trial measured libido gain directly, but in a retrospective cohort of men decreased libido was reported significantly less often on enclomiphene than on clomiphene.
Short answer
No trial measured libido gain directly, but in a retrospective cohort of men decreased libido was reported significantly less often on enclomiphene than on clomiphene.[1]
What the data show
The cohort was retrospective: men at one academic centre who had taken clomiphene and were later prescribed enclomiphene, so there was no placebo group.[1]
Testosterone rose by a median of 166 ng/dL on enclomiphene versus 98 on clomiphene, a gap that was not statistically significant.[1]
A short evidence review concludes that symptom improvement with these drugs is comparable to testosterone replacement, based on retrospective cohort data.[2]
More questions on Enclomiphene
More on Enclomiphene
Sources
- 1Safety and efficacy of enclomiphene and clomiphene for hypogonadal men.Translational andrology and urology · 2024PMID 39434750Accessed 2 Oct 2026
- 2Are SERMs safe and effective for the treatment of hypogonadism in men?The Journal of family practice · 2022PMID 35259334Accessed 2 Oct 2026
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