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Is enclomiphene a SERM?

Yes: a clinical evidence review groups enclomiphene citrate with clomiphene as a selective estrogen receptor modulator used for low testosterone in men.

SERM (not a peptide)Updated

Short answer

Yes: a clinical evidence review groups enclomiphene citrate with clomiphene as a selective estrogen receptor modulator used for low testosterone in men.[1]

What the SERM trials found

A meta-analysis of randomised trials of clomiphene and enclomiphene found SERM therapy raised total testosterone, with no significant difference from testosterone gel.[2]

In men with obesity-related androgen deficiency, pooled enclomiphene studies showed a testosterone rise of 7.50 nmol/L.[3]

A drug profile describes its action as an antagonist at the estrogen receptor that drives gonadotropin-dependent testosterone secretion.[4]

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More on Enclomiphene

How it worksTarget, mechanism and how long it acts, from the label or studies.Enclomiphene overview

Sources

  1. 1Are SERMs safe and effective for the treatment of hypogonadism in men?The Journal of family practice · 2022PMID 35259334Accessed 2 Oct 2026
  2. 2Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials.Archives of endocrinology and metabolism · 2025PMID 41066380Accessed 2 Oct 2026
  3. 3Selective modulation of estrogen receptor in obese men with androgen deficiency: A systematic review and meta-analysis.Andrology · 2023PMID 36604313Accessed 2 Oct 2026
  4. 4Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men.IDrugs : the investigational drugs journal · 2009PMID 19204885Accessed 11 Oct 2026

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