Is enclomiphene a steroid?
No. A review of the compound places it as one of the two isomers of clomiphene, which is described as a non-steroidal estrogen receptor antagonist, so it is not a steroid hormone.
Short answer
No. A review of the compound places it as one of the two isomers of clomiphene, which is described as a non-steroidal estrogen receptor antagonist, so it is not a steroid hormone.[1]
A drug profile calls enclomiphene itself a non-steroidal estrogen receptor antagonist and says its effect on testosterone runs through gonadotropin signalling to the testes.[2]
How it raises testosterone
Rather than supplying a hormone, enclomiphene is described as acting on the brain-to-testis signalling axis so the body makes more of its own testosterone while sperm production is maintained.[3]
In a phase II trial this showed up as higher luteinizing hormone alongside higher testosterone, the pattern expected from a drug acting upstream of the testes.[4]
More questions on Enclomiphene
More on Enclomiphene
Sources
- 1Enclomiphene citrate for the treatment of secondary male hypogonadism.Expert opinion on pharmacotherapy · 2016PMID 27337642Accessed 2 Oct 2026
- 2Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men.IDrugs : the investigational drugs journal · 2009PMID 19204885Accessed 11 Oct 2026
- 3Preserving spermatogenesis in testosterone deficiency: innovations in replacement and stimulatory therapies.Translational andrology and urology · 2025PMID 41522318Accessed 2 Oct 2026
- 4Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.Fertility and sterility · 2014PMID 25044085Accessed 2 Oct 2026
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