What happens when you stop taking enclomiphene?
In a small phase IIB trial, testosterone fell back to pretreatment values one month after enclomiphene treatment ended.
SERM (not a peptide)Updated
Short answer
In a small phase IIB trial, testosterone fell back to pretreatment values one month after enclomiphene treatment ended.[1]
What was measured after treatment ended
In a dose-comparison phase II study, the rises in LH and testosterone carried on after stopping, for at least a week.[2]
Sperm counts stayed higher at follow-up in men who had taken enclomiphene, unlike men who had used testosterone gel.[1]
That trial enrolled only 12 men with secondary hypogonadism, so the pattern after stopping is based on very few people.[1]
More questions on Enclomiphene
More on Enclomiphene
Sources
- 1Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.The journal of sexual medicine · 2013PMID 23530575Accessed 2 Oct 2026
- 2Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics.BJU international · 2013PMID 23875626Accessed 2 Oct 2026
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